![]() Nifedipine was reduced with Zn/HCl reduction system and then the diazo coupling reaction was carried out with the CDNBD reagent to generate a new azo adduct with optimal wavelength at 470 nm representing a bathochromic shift relative to nifedipine, reduced nifedipine and CDNBD reagent. ![]() Judging from the various generic brands currently now available, this research was conceived as a means of developing an alternative cost-effective and readily adaptable method for the assay of nifedipine in tablets and for which official high performance liquid chromatographic technique may not be readily available. A new sensitive colorimetric determination of nifedipine has been developed following azo dye formation with 4-carboxyl-2,6-dinitrobenzenediazonium ion (CDNBD).
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